What is translation initiation?

Asked by: Dahlia Horu

asked in category: General Last Updated: 5th April, 2020

What is translation initiation?

Translation initiation is a complex process in which initiator tRNA, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the initiation codon of mRNA. Initiation on a few mRNAs is cap-independent and occurs instead by internal ribosomal entry.

Similarly one may ask, what happens during translation initiation?

Initiation of translation occurs when mRNA, tRNA, and an amino acid meet up inside the ribosome. During elongation, amino acids are continually added to the line, forming a long chain bound together by peptide bonds. Once a stop codon reaches the ribosome, translation stops, or terminates.

One may also ask, what is the first step in the initiation of translation in bacteria? Translation Factors. The first translation step in bacteria is the binding of three initiation factors (IF-1, IF-2, and IF-3) to the 30S ribosomal subunit (Figure 7.9). The mRNA and initiator N-formylmethionyl tRNA then join the complex, with IF-2 (which is bound to GTP) specifically recognizing the initiator tRNA.

Also asked, what initiates translation in eukaryotes?

Eukaryotic translation initiation: Complex of small ribosomal subnit and initiator tRNA (bearing methionine) binds to 5′ cap of mRNA. Initiator tRNA binds to start codon. Large ribosomal subunit comes together with the mRNA, initiator tRNA, and small ribosomal subunit to form the initiation complex.

What initiates translation in prokaryotes?

Translation in bacteria begins with the formation of the initiation complex, which includes the small ribosomal subunit, the mRNA, the initiator tRNA carrying N-formyl-methionine, and initiation factors. Then the 50S subunit binds, forming an intact ribosome.

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